Oxium™Exo is a chemically-defined culture medium for the continuous production of small extracellular vesicles (sEVs) and exosomes. It is serum-free and devoid of animal and blood components.
Cell culture medium for exosomes production
661
Million USD, Global Exosome Research Market by 2026
35.6
CAGR for the 2021-2026 period
1,125
Percentage increase in exosome scholarly works in the last 15 years
“Oxium™Exo has been benchmarked by multiple international companies and is now commercially available in the US and Canada thanks to an ongoing partnership with an American life sciences company.”
Diego Castro, M.Sc., Project Manager
Cells cultured with Oxium™Exo secrete higher amounts of exosomes. Our comparative study confirmed the unique benefits that Oxium™Exo provides to exosome-producing cells. First, it maintains cell viability for at least six days without supplementation (FBS or hPL). Second, these cells had significantly higher viability and presented fewer apoptotic and cell death levels than those cultured in DMEM or commercial medium. Third, cells cultured in Oxium™Exo maintain the characteristics of Mesenchymal Stromal Cells (MSCs), as defined by the International Society for Cell and Gene Therapy (ISCT). Fourth, cells cultured in our media produced more than nine times more small extracellular vesicles than competitors after six days. This edge over other media is even greater for those vesicles between 50 to 200 nanometers.
Oxium™Exo-derived vesicles are internalized by target cells and maintain their biodistribution profile. It is critical that a cell culture media that enhances the secretion rate of sEVs also does not modify their structural, biochemical, and classical properties. This positive impact was determined mainly by the internalization capacity of Oxium™Exo-produced sEVs in cartilage and cancer cells in vitro and by the biodistribution profile in vivo. Our research concluded that the surface markers, cell uptake, and biodistribution pattern of sEV are not affected by the use of Oxium™Exo.
Only chemically defined components and no background noise. Chemical definition of cell culture media is vital for addressing CMC issues and regulatory requirements that ultimately lead to achieving clinical-grade production of exosome therapeutics. Oxium™Exo is a premier chemically defined media with negligible background noise (less than 10E-6 particles per mL) as it is devoid of animal and blood components. These features make Oxium™Exo the ideal choice for therapeutic developers seeking to produce large quantities of sEVs for clinical applications.
