CD49b Targeting Inhibits Tumor Growth and Boosts Anti-tumor Immunity

Contreras-Kallens, P., Gálvez-Jirón, F., De Solminihac, J., Elhusseiny, A., González-Arriagada, W. A., Alcayaga-Miranda, F., Noelle, R. J. & Pino-Lagos, K., 4 Jul 2022, In: Frontiers in Oncology. 12, 928498.

Delivery of affordable and scalable encapsulated allogenic/autologous mesenchymal stem cells in coagulated platelet poor plasma for dental pulp regeneration

Angelopoulos, I., Trigo, C., Ortuzar, M. I., Cuenca, J., Brizuela, C. & Khoury, M., 10 Jan 2022, In: Scientific Reports. 12, 1, p. 435 435.

Mesenchymal stem cell-mediated transfer of mitochondria: mechanisms and functional impact

Velarde, F., Ezquerra, S., Delbruyere, X., Caicedo, A., Hidalgo, Y. & Khoury, M., 5 Mar 2022, In: Cellular and Molecular Life Sciences. 79, 3, p. 177 1 p., 177.

Turning adversity into opportunity: Small extracellular vesicles as nanocarriers for tumor-associated macrophages re-education

Donoso-Meneses, D., Figueroa-Valdés, A. I., Georges, N., Tobar, H. E. & Alcayaga-Miranda, F., 2022, (Accepted/In press) In: Bioengineering and Translational Medicine.

A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem Cells

Figueroa-Valdés, A. I., de la Fuente, C., Hidalgo, Y., Vega-Letter, A. M., Tapia-Limonchi, R., Khoury, M. & Alcayaga Miranda, F., 26 May 2021, In: Frontiers in Bioengineering and Biotechnology. 9, p. 619930 619930.

Camouflage strategies for therapeutic exosomes evasion from phagocytosis

Parada, N., Romero-Trujillo, A., Georges, N. & Alcayaga Miranda, F., 1 Jul 2021, In: Journal of Advanced Research. 31, p. 61-74 14 p.

Editorial: The Role of Metabolism in MSC-Mediated Immunomodulation

Pers, Y. M., Jorgensen, C. & Khoury, M., 26 Aug 2021, In: Frontiers in Immunology. 12, 751865.

Mitochondrial MicroRNAs Contribute to Macrophage Immune Functions Including Differentiation, Polarization, and Activation

Duroux-Richard, I., Apparailly, F. & Khoury, M., 3 Nov 2021, In: Frontiers in Physiology. 12, p. 738140 738140.

Mitochondria-Rich Fraction Isolated from Mesenchymal Stromal Cells Reduces Lung and Distal Organ Injury in Experimental Sepsis∗

De Carvalho, L. R. P., Abreu, S. C., De Castro, L. L., Andrade Da Silva, L. H., Silva, P. M., Vieira, J. B., Santos, R. T., Cabral, M. R., Khoury, M., Weiss, D. J., Lopes-Pacheco, M., Silva, P. L., Cruz, F. F. & Rocco, P. R. M., Sep 2021, In: Critical Care Medicine. 49, 9, p. E880-E890

Musculoskeletal Progenitor/Stromal Cell-Derived Mitochondria Modulate Cell Differentiation and Therapeutical Function

Jorgensen, C. & Khoury, M., 8 Mar 2021, In: Frontiers in Immunology. 12, p. 606781 606781.

Soluble neuropilin-1 in gingival crevicular fluid is associated with rheumatoid arthritis: An exploratory case-control study

Prieto, D., González, C., Weber, L., Realini, O., Pino-Lagos, K., Bendek, M. J., Retamal, I., Beltrán, V., Riedemann, J. P., Espinoza, F. & Chaparro, A., 1 Apr 2021, In: Journal of Oral Biology and Craniofacial Research. 11, 2, p. 303-307 5 p.

The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential

Contreras-Lopez, R., Elizondo-Vega, R., Luque-Campos, N., Torres, M. J., Pradenas, C., Tejedor, G., Paredes-Martínez, M. J., Vega-Letter, A. M., Campos-Mora, M., Rigual-Gonzalez, Y., Oyarce, K., Salgado, M., Jorgensen, C., Khoury, M., Garcia-Robles, M. D. L. Á., Altamirano, C., Djouad, F. & Luz-Crawford, P., 2021, In: Theranostics. 11, 1, p. 445-460 16 p.

Allogeneic Cellular Therapy in a Mature Tooth with Apical Periodontitis and Accidental Root Perforation: A Case Report

Cordero, C. B., Santander, G. M., González, D. U., Quezada, A., Silva, C. I., Vásquez, C., Jara, R., Jara, D. & Khoury, M., Dec 2020, In: Journal of Endodontics. 46, 12, p. 1920-1927.e1

Cell-Based Regenerative Endodontics for Treatment of Periapical Lesions: A Randomized, Controlled Phase I/II Clinical Trial

Brizuela, C., Meza, G., Urrejola, D., Quezada, M. A., Concha, G., Ramírez, V., Angelopoulos, I., Cadiz, M. I., Tapia-Limonchi, R. & Khoury, M., 1 May 2020, In: Journal of Dental Research. 99, 5, p. 523-529 7 p.

Cell-based therapies for coronavirus disease 2019: proper clinical investigations are essential

Khoury, M., Rocco, P. R. M., Phinney, D. G., Krampera, M., Martin, I., Viswanathan, S., Nolta, J. A., LeBlanc, K., Galipeau, J. & Weiss, D. J., Nov 2020, In: Cytotherapy. 22, 11, p. 602-605 4 p.

Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19

Khoury, M., Cuenca, J., Cruz, F. F., Figueroa, F. E., Rocco, P. R. M. & Weiss, D. J., 1 Jun 2020, In: European Respiratory Journal. 55, 6, 2000858.

Generation of Functional Stem Cell-Derived CD105neg CD73low Melanocyte Precursors Guided by Defined Culture Conditions

Zavala, G., Sandoval, C., Meza, D., Contreras, R., Gubelin, W. & Khoury, M., 24 Mar 2020, In: SSRN Electronic Journal.

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HIF1α-dependent metabolic reprogramming governs mesenchymal stem/stromal cell immunoregulatory functions

Contreras-Lopez, R., Elizondo-Vega, R., Paredes, M. J., Luque-Campos, N., Torres, M. J., Tejedor, G., Vega-Letter, A. M., Figueroa-Valdés, A., Pradenas, C., Oyarce, K., Jorgensen, C., Khoury, M., Garcia-Robles, M. D. L. A., Altamirano, C., Djouad, F. & Luz Crawford, P. A., 1 Jun 2020, In: FASEB Journal. 34, 6, p. 8250-8264 15 p.

Magic realism: a Latin American paradigm for stem cell research & development?

Khoury, M. & Figueroa, F. E., 1 Feb 2020, In: Gene Therapy. 27, 1-2, p. 2-5 4 p.

Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response

Court, A. C., Le-Gatt, A., Luz-Crawford, P., Parra, E., Aliaga-Tobar, V., Bátiz, L. F., Contreras, R. A., Ortúzar, M. I., Kurte, M., Elizondo-Vega, R., Maracaja-Coutinho, V., Pino-Lagos, K., Figueroa, F. E. & Khoury, M., 5 Feb 2020, In: EMBO Reports. 21, 2, e48052.

PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties

Contreras-Lopez, R. A., Elizondo-Vega, R., Torres, M. J., Vega-Letter, A. M., Luque-Campos, N., Paredes-Martinez, M. J., Pradenas, C., Tejedor, G., Oyarce, K., Salgado, M., Jorgensen, C., Khoury, M., Kronke, G., Garcia-Robles, M. A., Altamirano, C., Luz Crawford, P. A. & Djouad, F., 1 Dec 2020, In: Scientific Reports. 10, 1, 11423.

Semipermeable Cellulose Beads Allow Selective and Continuous Release of Small Extracellular Vesicles (sEV) From Encapsulated Cells

Zavala, G., Ramos, M. P., Figueroa-Valdés, A. I., Cisternas, P., Wyneken, U., Hernández, M., Toa, P., Salmons, B., Dangerfield, J., Gunzburg, W. H. & Khoury, M., 21 May 2020, In: Frontiers in Pharmacology. 11, 679.

Single cell migration profiling on a microenvironmentally tunable hydrogel microstructure device that enables stem cell potency evaluation

Ros, E., Encina, M., González, F., Contreras, R., Luz-Crawford, P., Khoury, M. & Acevedo, J. P., 7 Mar 2020, In: Lab on a Chip. 20, 5, p. 958-972 15 p.

The Coronavirus Pandemic: A Pitfall or a Fast Track for Validating Cell Therapy Products?

Khoury, M., Ikonomou, L., Dominici, M., Le Blanc, K., Levine, B. L. & Weiss, D. J., 14 Dec 2020, In: Stem Cells and Development. 30, 3, p. 119-127 9 p.

Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE.

Kurte, M., Vega-Letter, A. M., Luz Crawford, P. A., Djouad, F., Noël, D., Khoury, M. & Carrión, F., 25 Sep 2020, In: Stem Cell Research and Therapy. 11, 1, 416.

¿La periodontitis crónica modifica la morbilidad de la artritis reumatoide? Aspectos clínicos y moleculares. Una revisión sistemática

Translated title of the contribution: Association between chronic periodontitis and rheumatoid arthritis. A systematic review

Wen, S., Beltrán, V., Chaparro, A., Espinoza, F. & Riedemann, J. P., 2019, In: Revista Medica de Chile. 147, 6, p. 762-775 14 p.

Adipose tissue-derived mesenchymal stromal cells in patients with chronic kidney disease: A pilot study assessing safety and clinical feasibility

Villanueva, S., González, F., Lorca, E., Tapia, A., Valentina López, G., Strodthoff, R., Fajre, F., Carreño, J. E., Valjalo, R., Vergara, C., Lecanda, M., Bartolucci, J., Figueroa, F. E. & Khoury, M., 2019, In: Kidney Research and Clinical Practice. 38, 2, p. 176-185 10 p.

Angiogenic properties of menstrual stem cells are impaired in women with a history of preeclampsia

Varas-Godoy, M., Acuña-Gallardo, S., Venegas-Duarte, S., Hill, C., Caceres-Verschae, A., Realini, O., Monteiro, L., Zavala, G., Khoury, M., Romero, R., Rice, G. & Illanes, S., 2019, In: Stem Cells International. 2019, 1916542.

Author Correction: Rapid fabrication of reinforced and cell-laden vascular grafts structurally inspired by human coronary arteries (Nature Communications, (2019), 10, 1, (3098), 10.1038/s41467-019-11090-3)

Akentjew, T. L., Terraza, C., Suazo, C., Maksimcuka, J., Wilkens, C. A., Vargas, F., Zavala, G., Ocaña, M., Enrione, J., García-Herrera, C. M., Valenzuela, L. M., Blaker, J. J., Khoury, M. & Acevedo, J. P., 1 Dec 2019, In: Nature Communications. 10, 1, 3508.

Cold-adaptation of a methacrylamide gelatin towards the expansion of the biomaterial toolbox for specialized functionalities in tissue engineering

Zaupa, A., Byres, N., Dal Zovo, C., Acevedo, C. A., Angelopoulos, I., Terraza, C., Nestle, N., Abarzúa-Illanes, P. N., Quero, F., Díaz-Calderón, P., Olguín, Y., Akentjew, T. L., Wilkens, C. A., Padilla, C., Zacconi, F. C., Pino-Lagos, K., Blaker, J. J., Khoury, M., Enrione, J. & Acevedo, J. P., Sep 2019, In: Materials Science and Engineering C. 102, p. 373-390 18 p.

Composition comprising a substantially pure population of multipotent stromal cells encapsulated in platelet-poor plasma (PPP).

Khoury, M., Brizuela, C., Angelopoulos, I., Khoury, M., Brizuela, C. & Angelopoulos, I., 5 Dec 2019, IPC No. A61K 35/ 51 A I, Patent No. US2019365804, Priority date 15 Jan 2018, Priority No. WO2018IB50243

Differentiation of adipose-derived stem cells to functional CD105neg CD73low melanocyte precursors guided by defined culture condition

Zavala, G., Sandoval, C., Meza, D., Contreras, R., Gubelin, W. & Khoury, M., 9 Aug 2019, In: Stem Cell Research and Therapy. 10, 1, 249.

Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity

Schuh, C. M. A. P., Aguayo, S., Zavala, G. & Khoury, M., 2019, In: Journal of Experimental Biology. 222, 20, jeb.208702.

Exosomes on the border of species and kingdom intercommunication

Schuh, C. M. A. P., Cuenca, J., Alcayaga-Miranda, F. & Khoury, M., Aug 2019, In: Translational Research. 210, p. 80-98 19 p.

Mesenchymal stem cells improve rheumatoid arthritis progression by controlling memory T cell response

Luque-Campos, N., Contreras-López, R. A., Paredes-Martínez, M. J., Torres, M. J., Bahraoui, S., Wei, M., Espinoza, F., Djouad, F., Elizondo-Vega, R. J. & Luz Crawford, P. A., 2019, In: Frontiers in Immunology. 10, MAR, 798.

Personalized Cell Therapy for Pulpitis Using Autologous Dental Pulp Stem Cells and Leukocyte Platelet-rich Fibrin: A Case Report

Meza, G., Urrejola, D., Saint Jean, N., Inostroza, C., López, V., Khoury, M. & Brizuela, C., Feb 2019, In: Journal of Endodontics. 45, 2, p. 144-149 6 p.

Primary allogeneic mitochondrial mix (PAMM) transfer/transplant by MitoCeption to address damage in PBMCs caused by ultraviolet radiation

Cabrera, F., Ortega, M., Velarde, F., Parra, E., Gallardo, S., Barba, D., Soto, L., Peña, G., Pedroza, L. A., Jorgensen, C., Khoury, M. & Caicedo, A., 28 Jun 2019, In: BMC Biotechnology. 19, 1, 42.

Rapid fabrication of reinforced and cell-laden vascular grafts structurally inspired by human coronary arteries

Akentjew, T. L., Terraza, C., Suazo, C., Maksimuck, J., Wilkens, C. A., Vargas, F., Zavala, G., Ocaña, M., Enrione, J., García-Herrera, C. M., Valenzuela, L. M., Blaker, J. J., Khoury, M. & Acevedo, J. P., 1 Dec 2019, In: Nature Communications. 10, 1, 3098.

Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma

Rosenberger, L., Ezquer, M., Lillo-Vera, F., Pedraza, P. L., Ortúzar, M. I., González, P. L., Figueroa-Valdés, A. I., Cuenca, J., Ezquer, F., Khoury, M. & Alcayaga-Miranda, F., 1 Dec 2019, In: Scientific Reports. 9, 1, 663.

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

Matas, J., Orrego, M., Amenabar, D., Infante, C., Tapia-Limonchi, R., Cadiz, M. I., Alcayaga-Miranda, F., González, P. L., Muse, E., Khoury, M., Figueroa, F. E. & Espinoza, F., Mar 2019, In: Stem cells translational medicine. 8, 3, p. 215-224 10 p.

Gingival Mesenchymal Stem Cells Outperform Haploidentical Dental Pulp-derived Mesenchymal Stem Cells in Proliferation Rate, Migration Ability, and Angiogenic Potential

Angelopoulos, I., Brizuela, C. & Khoury, M., 1 Jun 2018, In: Cell Transplantation. 27, 6, p. 967-978 12 p.

IL17/IL17RA as a novel signaling axis driving mesenchymal stem cell therapeutic function in experimental autoimmune encephalomyelitis

Kurte, M., Luz-Crawford, P., Vega-Letter, A. M., Contreras, R. A., Tejedor, G., Elizondo-Vega, R., Martinez-Viola, L., Fernández-O’Ryan, C., Figueroa, F. E., Jorgensen, C., Djouad, F. & Carrión, F., 30 Apr 2018, In: Frontiers in Immunology. 9, APR, 802.

Implementación de una unidad de artritis reumatoide temprana en pacientes chilenos derivados desde centros de atención primaria de salud

Translated title of the contribution: Implementation of an early rheumatoid athritis unit for the early recognition and treatment of the disease

Espinoza, F., Monckeberg, G., Hassi, I., Queirolo, A., Chicao, F., Sandoval, X., Jorquera, E. & Badilla, A., Jan 2018, In: Revista Medica de Chile. 146, 1, p. 39-45 7 p.

Injection of adipose-derived stromal cells in the knee of patients with severe osteoarthritis has a systemic effect and promotes an anti-inflammatory phenotype of circulating immune cells

Pers, Y. M., Quentin, J., Feirreira, R., Espinoza, F., Abdellaoui, N., Erkilic, N., Cren, M., Dufourcq-Lopez, E., Pullig, O., Nöth, U., Jorgensen, C. & Louis-Plence, P., 2018, In: Theranostics. 8, 20, p. 5519-5528 10 p.

Microtechnology applied to stem cells research and development

Acevedo, J. P., Angelopoulos, I., Van Noort, D. & Khoury, M., Mar 2018, In: Regenerative Medicine. 13, 2, p. 233-248 16 p.

The reparative abilities of menstrual stem cells modulate the wound matrix signals and improve cutaneous regeneration

Cuenca, J., Le-Gatt, A., Castillo, V., Belletti, J., Díaz, M., Kurte, G. M., Gonzalez, P. L., Alcayaga-Miranda, F., Schuh, C. M. A. P., Ezquer, F., Ezquer, M. & Khoury, M., 14 May 2018, In: Frontiers in Physiology. 9, MAY, 464.

Anti-angiogenic therapy based on exosomes derived from menstrual stem cells

Alcayaga-Miranda, F. & Khoury, M., 2017, (Accepted/In press) IPC No. A61K 35/14 2015.1, A61K 35/28 2015.1, A61P 35/00 2006.1, C12N 5/0775 2010.1, C12N 5/078 2010.1, Patent No. WO/2017/064647, Priority date 13 Oct 2015, Priority No. 62/240,756

Antimicrobial activity of mesenchymal stem cells: current status and new perspectives of antimicrobial peptide-based therapies

Alcayaga-Miranda, F., Cuenca, J. & Khoury, M., 30 Mar 2017, In: Frontiers in Immunology. 8, MAR, 339.

Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications

Caicedo, A., Aponte, P. M., Cabrera, F., Hidalgo, C. & Khoury, M., 2 Jul 2017, In: Stem Cells International. 2017, 7610414.

Biologic disease-modifying antirheumatic drug (bdmard)-induced neutropenia: A registry from a retrospective cohort of patients with rheumatic diseases treated with 3 classes of intravenous bdmard

Espinoza, F., Le Blay, P. & Combe, B., 1 Jun 2017, In: Journal of Rheumatology. 44, 6, p. 844-849 6 p.

Bioprinted 3D vascularized tissue model for drug toxicity analysis

Massa, S., Sakr, M. A., Seo, J., Bandaru, P., Arneri, A., Bersini, S., Zare-Eelanjegh, E., Jalilian, E., Cha, B. H., Antona, S., Enrico, A., Gao, Y., Hassan, S., Acevedo, J. P., Dokmeci, M. R., Zhang, Y. S., Khademhosseini, A. & Shin, S. R., 1 Jul 2017, In: Biomicrofluidics. 11, 4, 044109.

Layer-by-layer approach for a uniformed fabrication of a cell patterned vessel-like construct

Wilkens, C. A., Rivet, C. J., Akentjew, T. L., Alverio, J., Khoury, M. & Acevedo, J. P., Mar 2017, In: Biofabrication. 9, 1, 015001.

One-step combined focused epPCR and saturation mutagenesis for thermostability evolution of a new cold-active xylanase

Acevedo, J. P., Reetz, M. T., Asenjo, J. A. & Parra, L. P., 1 May 2017, In: Enzyme and Microbial Technology. 100, p. 60-70 11 p.

Safety and efficacy of the intravenous infusion of umbilical cord mesenchymal stem cells in patients with heart failure: A phase 1/2 randomized controlled trial (RIMECARD trial [Randomized clinical trial of intravenous infusion umbilical cord mesenchymal stem cells on cardiopathy])

Bartolucci, J., Verdugo, F. J., González, P. L., Larrea, R. E., Abarzua, E., Goset, C., Rojo, P., Palma, I., Lamich, R., Pedreros, P. A., Valdivia, G., Lopez, V. M., Nazzal, C., Alcayaga-Miranda, F., Cuenca, J., Brobeck, M. J., Patel, A. N., Figueroa, F. E. & Khoury, M., 2017, In: Circulation Research. 121, 10, p. 1192-1204 13 p.

Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE

Vega-Letter, A. M., Kurte, M., Fernández-O’Ryan, C., Gauthier-Abeliuk, M., Fuenzalida, P., Moya-Uribe, I., Altamirano, C., Figueroa, F., Irarrázabal, C. & Carrión, F., 10 Oct 2016, In: Stem Cell Research and Therapy. 7, 1, p. 1-12 12 p., 150.

Escenario actual y perspectivas de la terapia con células madre mesenquimales en medicina intensiva

Translated title of the contribution: Overview and perspectives of mesenchymal stem cell therapy in intensive care medicine

Espinoza, F., Aliaga, F. & Crawford, P. L., Feb 2016, In: Revista Medica de Chile. 144, 2, p. 222-231 10 p.

Harnessing the angiogenic potential of stem cell-derived exosomes for vascular regeneration

Alcayaga-Miranda, F., Varas-Godoy, M. & Khoury, M., 2016, In: Stem Cells International. 2016, 14 p., 3409169.

Mesenchymal stem cell-derived exosomes from different sources selectively promote neuritic outgrowth

Lopez-Verrilli, M. A., Caviedes, A., Cabrera, A., Sandoval, S., Wyneken, U. & Khoury, M., 21 Apr 2016, In: Neuroscience. 320, p. 129-139 11 p.

Mesenchymal stem cells and their immunosuppressive role in transplantation tolerance

Contreras-Kallens, P., Terraza, C., Oyarce, K., Gajardo, T., Campos-Mora, M., Barroilhet, M. T., Álvarez, C., Fuentes, R., Figueroa, F., Khoury, M. & Pino-Lagos, K., 2016, In: Annals of the New York Academy of Sciences. 1417, 1, p. 35-56 22 p.

Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression

Contreras, R. A., Figueroa, F. E., Djouad, F. & Luz-Crawford, P., 2016, In: Stem Cells International. 2016, 3162743.

Overexpression of glutamate decarboxylase in mesenchymal stem cells enhances their immunosuppressive properties and increases GABA and nitric oxide levels

Urrutia, M., Fernández, S., González, M., Vilches, R., Rojas, P., Vásquez, M., Kurte, M., Vega-Letter, A. M., Carrión, F., Figueroa, F., Rojas, P., Irarrázabal, C. & Fuentealba, R. A., Sep 2016, In: PLoS ONE. 11, 9, e0163735.

PPARβ/δ directs the therapeutic potential of mesenchymal stem cells in arthritis

Luz-Crawford, P., Ipseiz, N., Espinosa-Carrasco, G., Caicedo, A., Tejedor, G., Toupet, K., Loriau, J., Scholtysek, C., Stoll, C., Khoury, M., Noël, D., Jorgensen, C., Krönke, G. & Djouad, F., 1 Dec 2016, In: Annals of the Rheumatic Diseases. 75, 12, p. 2166-2174 9 p.

Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of reactive oxygen species

Alcayaga-Miranda, F., González, P. L., Lopez-Verrilli, A., Varas-Godoy, M., Aguila-Díaz, C., Contreras, L. & Khoury, M., 2016, In: Oncotarget. 7, 28, p. 44462-44477 16 p.

Remission-induction therapies for early rheumatoid arthritis: evidence to date and clinical implications

Espinoza, F., Fabre, S. & Pers, Y. M., 1 Aug 2016, In: Therapeutic Advances in Musculoskeletal Disease. 8, 4, p. 107-118 12 p.

The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases

Luz-Crawford, P., Torres, M. J., Noël, D., Fernandez, A., Toupet, K., Alcayaga-Miranda, F., Tejedor, G., Jorgensen, C., Illanes, S. E., Figueroa, F. E., Djouad, F. & Khoury, M., 1 Feb 2016, In: Stem Cells. 34, 2, p. 456-469 14 p.

Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model

Fuenzalida, P., Kurte, M., Fernández-O’ryan, C., Ibañez, C., Gauthier-Abeliuk, M., Vega-Letter, A. M., Gonzalez, P., Irarrázabal, C., Quezada, N., Figueroa, F. & Carrión, F., 1 May 2016, In: Cytotherapy. 18, 5, p. 630-641 12 p.

Characterization of menstrual stem cells: Angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells

Alcayaga-Miranda, F., Cuenca, J., Luz-Crawford, P., Aguila-Díaz, C., Fernandez, A., Figueroa, F. E. & Khoury, M., 17 Mar 2015, In: Stem Cell Research and Therapy. 6, 1, 32.

Chorion mesenchymal stem cells show superior differentiation, immunosuppressive, and angiogenic potentials in comparison with haploidentical maternal placental cells

González, P. L., Carvajal, C., Cuenca, J., Alcayaga-Miranda, F., Figueroa, F. E., Bartolucci, J., Salazar-Aravena, L. & Khoury, M., 1 Oct 2015, In: Stem cells translational medicine. 4, 10, p. 1109-1121 13 p.

Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis

Alcayaga-Miranda, F., Cuenca, J., Martin, A., Contreras, L., Figueroa, F. E. & Khoury, M., 16 Oct 2015, In: Stem Cell Research and Therapy. 6, 1, 199.

Directed evolution of phenylacetone monooxygenase as an active catalyst for the baeyer-villiger conversion of cyclohexanone to caprolactone

Parra, L. P., Acevedo, J. P. & Reetz, M. T., 1 Jul 2015, In: Biotechnology and Bioengineering. 112, 7, p. 1354-1364 11 p.

Intravenous administration of bone marrow-derived mesenchymal stem cells induces a switch from classical to atypical symptoms in experimental autoimmune encephalomyelitis

Kurte, M., Bravo-Alegría, J., Torres, A., Carrasco, V., Ibáñez, C., Vega-Letter, A. M., Fernández-O’Ryan, C., Irarrázabal, C. E., Figueroa, F. E., Fuentealba, R. A., Riedel, C. & Carrión, F., 2015, In: Stem Cells International. 2015, 140170.

Microrna profiling of b cell subsets from systemic lupus erythematosus patients reveals promising novel biomarkers

Duroux-Richard, I., Cuenca, J., Ponsolles, C., Piñeiro, A. B., Gonzalez, F., Roubert, C., Areny, R., Chea, R., Pefaur, J., Pers, Y. M., Figueroa, F. E., Jorgensen, C., Khoury, M. & Apparailly, F., 2015, In: International Journal of Molecular Sciences. 16, 8, p. 16953-16965 13 p.

Resultados a largo plazo del trasplante intracoronario de células mononucleares de médula ósea autólogas en pacientes con cardiopatía dilatada de diversa etiología

Translated title of the contribution: Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathy

Bartolucci, J., Verdugo, F. J., Carrion, F., Abarzúa, E., Goset, C., Lamich, R., Sanhueza, P., Pedreros, P., Nazzal, C., Khoury, M. & Figueroa, F. E., 2015, In: Revista Medica de Chile. 143, 4, p. 415-423 9 p.

Estado actual de la terapia con células madre en el tratamiento de las cardiopatías

Translated title of the contribution: Stem cells for the treatment of cardiovascular diseases. An update

Bartolucci Johnston, J., Verdugo, F. J., Larrea, R., Carrión, F., Lamich, R., Pedreros, P., Delgado, M., Sanhueza, P., Khoury, M. & Figueroa, F. E., 2014, In: Revista Medica de Chile. 142, 8, p. 1034-1046 13 p.

Innate immune system and preeclampsia

Perez-Sepulveda, A., Torres, M. J., Khoury, M. & Illanes, S. E., 2014, In: Frontiers in Immunology. 5, MAY, 244.

Menstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro

Alcayaga-Miranda, F. & Khoury, M., 2014, (Accepted/In press) Patent No. WO/2014/135924, Priority No. PCT/IB2013/051861

Novel approaches to lupus drug discovery using stem cell therapy. Role of mesenchymal-stem-cell-secreted factors

Figueroa, F. E., Cuenca Moreno, J. & La Cava, A., May 2014, In: Expert Opinion on Drug Discovery. 9, 5, p. 555-566 12 p.

Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes

Amador, C. A., Barrientos, V., Peña, J., Herrada, A. A., González, M., Valdés, S., Carrasco, L., Alzamora, R., Figueroa, F., Kalergis, A. M. & Michea, L., Apr 2014, In: Hypertension. 63, 4, p. 797-803 7 p.

The promising potential of menstrual stem cells for antenatal diagnosis and cell therapy

Khoury, M., Alcayaga-Miranda, F., Illanes, S. E. & Figueroa, F. E., 2014, In: Frontiers in Immunology. 5, MAY, 205.

A new type of stereoselectivity in Baeyer-Villiger reactions: Access to E- and Z-olefins

Zhang, Z. G., Roiban, G. D., Acevedo, J. P., Polyak, I. & Reetz, M. T., 14 Jan 2013, In: Advanced Synthesis and Catalysis. 355, 1, p. 99-106 8 p.

Cloning, expression and decoding of the cold adaptation of a new widely represented thermolabile subtilisin-like protease

Acevedo, J. P., Rodriguez, V., Saavedra, M., Muñoz, M., Salazar, O., Asenjo, J. A. & Andrews, B. A., Feb 2013, In: Journal of Applied Microbiology. 114, 2, p. 352-363 12 p.

Embarazos exitosos en hemodiálisis crónica: Experiencia de un único centro

Translated title of the contribution: Pregnancy during dialysis. Experience in six patients

Espinoza, F., Romeo, R., Ursu, M., Tapia, A. & Vukusich, A., 2013, In: Revista Medica de Chile. 141, 8, p. 1003-1009 7 p.

Erratum: Tuning a P450 enzyme for methane oxidation (Angewandte Chemie – International Edition (2011) 50 (2720-2724) DOI: 10.1002/anie.201006587)

Zilly, F. E., Acevedo, J. P., Augustyniak, W., Deege, A., Häusig, U. W. & Reetz, M. T., 16 Dec 2013, In: Angewandte Chemie – International Edition. 52, 51, p. 13503 1 p.

Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure

Villanueva, S., Carreño, J. E., Salazar, L., Vergara, C., Strodthoff, R., Fajre, F., Céspedes, C., Sáez, P. J., Irarrázabal, C., Bartolucci, J., Figueroa, F. & Vio, C. P., Aug 2013, In: Clinical Science. 125, 4, p. 199-210 12 p.

Hydrogel-coated microfluidic channels for cardiomyocyte culture

Annabi, N., Selimović, Š., Acevedo, J. P., Ribas, J., Afshar Bakooshli, M., Heintze, D., Weiss, A. S., Cropek, D. & Khademhosseini, A., 21 Sep 2013, In: Lab on a Chip. 13, 18, p. 3569-3577 9 p.

Increased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: A case control study

Chaparro, A., Sanz, A., Quintero, A., Inostroza, C., Ramirez, V., Carrion, F., Figueroa, F., Serra, R. & Illanes, S. E., Jun 2013, In: Journal of Periodontal Research. 48, 3, p. 302-307 6 p.

Mesenchymal stem cells generate a CD4+CD25+Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells

Luz-Crawford, P., Kurte, M., Bravo-Alegría, J., Contreras, R., Nova-Lamperti, E., Tejedor, G., Noël, D., Jorgensen, C., Figueroa, F., Djouad, F. & Carrión, F., 2013, In: Stem Cell Research and Therapy. 4, 3, 65.

Reducing codon redundancy and screening effort of combinatorial protein libraries created by saturation mutagenesis

Kille, S., Acevedo-Rocha, C. G., Parra, L. P., Zhang, Z. G., Opperman, D. J., Reetz, M. T. & Acevedo, J. P., 15 Feb 2013, In: ACS Synthetic Biology. 2, 2, p. 83-92 10 p.

Mesenchymal stem cells for the treatment of systemic lupus erythematosus: is the cure for connective tissue diseases within connective tissue?

Carrion, F. A. & Figueroa, F. E., 2011, In: Stem Cell Research and Therapy. 2, 3, 23.

Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model

Villanueva, S., Ewertz, E., Carrión, F., Tapia, A., Vergara, C., Céspedes, C., Sáez, P. J., Luz, P., Irarrázabal, C., Carreño, J. E., Figueroa, F. & Vio, C. P., Dec 2011, In: Clinical Science. 121, 11, p. 489-499 11 p.

Mesenchymal Stem Cell treatment for autoimmune diseases: A critical review

Figueroa, F. E., Carrión, F., Villanueva, S. & Khoury, M., 2012, In: Biological Research. 45, 3, p. 269-277 9 p.

Mesenchymal Stem Cells Repress Th17 Molecular Program through the PD-1 Pathway

Luz-Crawford, P., Noël, D., Fernandez, X., Khoury, M., Figueroa, F., Carrión, F., Jorgensen, C. & Djouad, F., 17 Sep 2012, In: PLoS ONE. 7, 9, e45272.

Mesenchymal stem cells in osteoarticular pediatric diseases: an update.

Norambuena, G. A., Khoury, M. & Jorgensen, C., Apr 2012, In: Pediatric Research. 71, 4 Pt 2, p. 452-458 7 p.

IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction

Ávalos, A. M., Apablaza, F. A., Quiroz, M., Toledo, V., Peña, J. P., Michea, L., Irarrázabal, C. E., Carrión, F. A. & Figueroa, F. E., 2012, In: Biological Research. 45, 2, p. 193-200 8 p.

Daño arterial asociado a la enfermedad renal crónica: Evaluación mediante técnicas de laboratorio no invasivo en pacientes hemodializados

Translated title of the contribution: Assesment of arterial damage by noninvasive peripheral arterial tonometry in non-diabetic hemodialysis patients

Espinoza, F., Kunstmann, S., Urzúa, A., Michea, L., Marusic, E. T. & Vukusich, A., Feb 2012, In: Revista Medica de Chile. 140, 2, p. 153-160 8 p.

Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4 + T cell activation.

Carrión, F., Nova, E., Luz, P., Apablaza, F. & Figueroa, F., 30 Mar 2011, In: Immunology Letters. 135, 1-2, p. 10-16 7 p.

Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity

Herrada, A. A., Contreras, F. J., Marini, N. P., Amador, C. A., González, P. A., Cortés, C. M., Riedel, C. A., Carvajal, C. A., Figueroa, F., Michea, L. F., Fardella, C. E. & Kalergis, A. M., 1 Jan 2010, In: Journal of Immunology. 184, 1, p. 191-202 12 p.

Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients

Carrion, F., Nova, E., Ruiz, C., Diaz, F., Inostroza, C., Rojo, D., MÖnckeberg, G. & Figueroa, F. E., Mar 2010, In: Lupus. 19, 3, p. 317-322 6 p.

Directed Evolution of Enantioconvergency: the Case of an Epoxide Hydrolase-Catalyzed Reaction of a Racemic Epoxide

Zheng, H., Kahakeaw, D., Acevedo, J. P. & Reetz, M. T., 9 Aug 2010, In: ChemCatChem. 2, 8, p. 958-961 4 p

Attenuation of NF-κB signalling in rat cardiomyocytes at birth restricts the induction of inflammatory genes

Goren, N., Cuenca, J., Martín-Sanz, P. & Boscá, L., 1 Nov 2004, In: Cardiovascular Research. 64, 2, p. 289-297 9 p.

Na +-K +-2Cl – cotransporter is implicated in gender differences in the response of the rat aorta to phenylephrine

Palacios, J., Espinoza, F., Munita, C., Cifuentes, F. & Michea, L., 12 Aug 2006, In: British Journal of Pharmacology. 148, 7, p. 964-972 9 p.

Tumores del Sistema Esquelético

Alcayaga-Miranda, F., Peña-Pla, M., Siracussa, C. & Pastor, J., 2007, Tumores del Sistema Esquelético. Gerosa, R. M. (ed.). Primera ed. Buenos Aires: Editorial Inter-Médica

Successful treatment of thrombotic thrombocytopenic purpura with vincristine report of one case

Espinoza, F., Leal Fernández, J. L. & Arenas, G., 1 Dec 2007, In: Revista Medica de Chile. 135, 12, p. 1572-1576 5 p.

Síndromes Paraneoplásicos

Alcayaga-Miranda, F., Peña-Pla, M., Siracussa, C. & Pastor, J., 2007, Geriatría Canina. Gerosa, R. M. (ed.). primera ed. Buenis Aires: Editorial Inter-Médica

Presence of bacterial DNA in valvular tissue of patients with rheumatic heart disease

Figueroa, F. E., Carrión A, F., Valenzuela M, S., Turner G, E., Aceitón E, C., Hirigoyen P, C., Bogdanic W, K., Solís D, C., Mansilla A, K. & Urra G, S., 1 Aug 2007, In: Revista Medica de Chile. 135, 8, p. 959-966 8 p.

Patient self-administered joint tenderness counts in rheumatoid arthritis are reliable and responsive to changes in disease activity

Figueroa, F., Braun-Moscovici, Y., Khanna, D., Voon, E., Gallardo, L., Luinstra, D., Pina, X., Henstorf, G., Laurence, S., Neiman, R. & Furst, D., 1 Jan 2007, In: Journal of Rheumatology. 34, 1, p. 54-56 3 p.

Infections in patients with systemic lupus erythematosus

Enberg G., M., Kahn C., M., Goity F., C., Villalón S., M. V., Zamorano R., J. & Figueroa E., F., 1 Oct 2009, In: Revista Medica de Chile. 137, 10, p. 1367-1374 8 p.

Polymorphisms of Fcγlla receptors in Chilean patients with systemic lupus erythematosus

Carrión A, F., Figueroa E, F., Martínez R, M. E., Massardo V, L., Pérez G, T., Foster B, C., Mancilla M, C., Neira Q, O., Guzmán B, L., Valenzuela M, V., Urrutia L, R., Carmona G, S., Figueroa, M., Lubiano A, A. & Wainstein G, E., 1 Jan 2003, In: Revista Medica de Chile. 131, 1, p. 11-18 8 p.

Selective depletion of Vβ2+CD8+ Tcells in peripheral blood from rheumatic heart disease patients

Carrión, F., Fernandez, M., Iruretagoyena, M., Coelho Andrade, L. E., Odete-Hilário, M. & Figueroa, F., Mar 2003, In: Journal of Autoimmunity. 20, 2, p. 183-190 8 p.

Eosinophilic fasciitis: Report of three cases

Velásquez G, X., Gutiérrez T, M. A., Rosenberg G, H., Figueroa E, F., Bronstein A, E. & Jacobelli G., S., 1 Feb 2002, In: Revista Medica de Chile. 130, 2, p. 209-214 6 p.

Restriction in the usage of variable β regions in T-cells infiltrating valvular tissue from rheumatic heart disease patients

Figueroa, F., González, M., Carrión, F., Lobos, C., Turner, F., Lasagna, N. & Valdés, F., Dec 2002, In: Journal of Autoimmunity. 19, 4, p. 233-240 8 p.

Tumor necrosis factor alpha genetic polymorphism as a risk factor in disease

Aguillón G, J. C., Cruzat C, A., Cuenca M, J. & Cuchacovich T, M., 1 Sep 2002, In: Revista Medica de Chile. 130, 9, p. 1043-1050 8 p.

Prospective comparison of clinical and echocardiographic diagnosis of rheumatic carditis: Long term follow up of patients with subclinical disease

Figueroa, F. E., Valdés, P., Carrión, F., Valdés, F., Soledad Fernández, M., Wilson, C., Berríos, X. & Lanas, F., 2001, In: Heart. 85, 4, p. 407-410 4 p.

La inmunología clínica actual: una perspectiva genética y molecular

Carrión A, F., Figueroa, F. E. & Rodríguez G, C., 1 Jun 2000, In: Revista Medica de Chile. 128, 6, p. 650-658 9 p.

Silicon Quantum Dot in a Metal-Oxide-Semiconductor Field Effect Transistor (MOSFET) Structure

Khoury, M., Gunther, A., Pivin, D. P. . J., Rack, M. & Ferry, D., 1999, In: Japanese Journal of Applied Physics. 38, 1B, p. 469

Efectos de la bromocriptina en pacientes con artritis reumatoide activa

Translated title of the contribution: Effects of bromocriptine in patients with active rheumatoid arthritis

Figueroa E, F., Carrión A, F., Martínez R, M. E., Rivero D, S., Mamani V, I. & González V, G., Jan 1998, In: Revista Medica de Chile. 126, 1, p. 33-41 9 p.

Gillespie syndrome phenotype with a t(X;11)(p22.32;p12) de novo translocation

Dollfus, H., Joanny-Flinois, O., Doco-Fenzy, M., Veyre, L., Joanny-Flinois, L., Khoury, M., Jonveaux, P., Abitbol, M. & Dufier, J. L., Mar 1998, In: American Journal of Ophthalmology. 125, 3, p. 397-399 3 p.

Bromocriptine induces immunological changes related to disease parameters in rheumatoid arthritis [1]

Figueroa, F., Carrion, F., Martinez, M. E., Rivero, S. & Mamani, I., 1997, In: British Journal of Rheumatology. 36, 9, p. 1022-1027

Effect of molecular weight on poly(methyl methacrylate) resolution

Khoury, M. & Ferry, D. K., 1996, In: Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures. 14, 1, p. 75-79

Association of primary antiphospholipid syndrome with primary adrenal insufficiency

González, G., Gutiérrez, M., Ortiz, M., Tellez, R., Figueroa, F. & Jacobelli, S., 1 Aug 1996, In: Journal of Rheumatology. 23, 7, p. 1286-1287 2 p.

Nanoscale Lithography with Electron Exposure of SiO 2 Resists

Whidden, T., Allgair, J., Jenkins-Gray, A., Khoury, M., Kozicki, M. & Ferry, D., 1 Aug 1995, In: Japanese Journal of Applied Physics. 34, 8B, p. 4420

Anticardiolipin antibodies in acute rheumatic fever

Figueroa, F., Berrios, X., Gutierrez, M., Carrion, F., Pablo Goycolea, J., Riedel, I. & Jacobelli, S., 1992, In: Journal of Rheumatology. 19, 8, p. 1175-1180 6 p.

Enfermedad del tejido conectivo materna asociada a bloqueo av congenito

Translated title of the contribution: Maternal connective tissue disease associated with congenital AV block

Gutiérrez, M., Figueroa, F., Rivero, S., Salles, J. P., Arnaiz, P., Cruzat, L. & Jacobelli, S., Jul 1989, In: Revista Medica de Chile. 117, 7, p. 789-793 5 p.