There is a need for advanced treatments based on regenerative endodontics strategies. Dental caries is the most pervasive noncommunicable disease, ranking first cause of permanent tooth decay. While many patients with cavities undergo the complete removal of the pulp (pulpectomy), patients that have received root canal therapy often face problems with the vitality of the dental pulp and the fragility of the tooth in the long term. To avoid complete tooth replacement, advanced treatments able to promote healthy dental pulp vascularization, re-innervation, and dentin deposition are needed. Regenerative Endodontic Procedures (REPs) have sought to achieve this goal, although with limited success. Traditional REPs that use a mature teeth bleeding technique or autologous therapy have drawbacks. The most notable problem affecting the two options is donor variability. Variations in cell concentration and composition, particularly in older patients (whose circulating stem cell concentrations may be lower in quantity and quality), may result in treatment outcome differences. In this context, researchers from Cells for Cells and Universidad de los Andes’ school of dentistry collaborated to create Cellistem®ER, a novel treatment for dental pulp regeneration.